The hoary marmot was eaten by Native Americans and the hides were used to make clothing and bedding items. Hides were also used in potlatch ceremonies and as a form of currency among the Tlingit and Gitksan tribes. Traditionally four tribal groups of the Pacific Northwest — Nootka, Kwakiutl, Tsimshian, and Tlingit — hunted marmots in the autumn after molting and before hibernation.
Marmots are popular with wildlife viewers. In areas where they are not hunted or harassed by dogs they can become quite habituated to people and can be closely approached.